CAS 13411-16-0|Nifurpirinol
| Common Name | Nifurpirinol | ||
|---|---|---|---|
| CAS Number | 13411-16-0 | Molecular Weight | 246.21900 |
| Density | 1.412 g/cm3 | Boiling Point | 416.3ºC at 760 mmHg |
| Molecular Formula | C12H10N2O4 | Melting Point | 170-171° |
| MSDS | ChineseUSA | Flash Point | 205.6ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | [6-[(E)-2-(5-nitrofuran-2-yl)ethenyl]pyridin-2-yl]methanol |
|---|---|
| Synonym | More Synonyms |
Nifurpirinol BiologicalActivity
| Description | Nifurpirinol (P-7138) is a nitroaromatic antibiotic and acts as a novel substrate for the bacterial nitroreductase (NTR) enzyme. Nifurpirinol is a more potent prodrug compared to Metronidazole to trigger cell-ablation in nitroreductase expressing transgenic models[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| Target | IC50: bacterial nitroreductase (NTR) enzyme[1] |
| References | [1]. David Bergemann, et al. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen |
Chemical & Physical Properties
| Density | 1.412 g/cm3 |
|---|---|
| Boiling Point | 416.3ºC at 760 mmHg |
| Melting Point | 170-171° |
| Molecular Formula | C12H10N2O4 |
| Molecular Weight | 246.21900 |
| Flash Point | 205.6ºC |
| Exact Mass | 246.06400 |
| PSA | 92.08000 |
| LogP | 2.76870 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.695 |
| InChIKey | JQKHJQJVKRFMCO-SNAWJCMRSA-N |
| SMILES | O=[N+]([O-])c1ccc(C=Cc2cccc(CO)n2)o1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 48,291,1973
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 48,291,1973
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| RTECS | UT5023000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles5
More Articles| Correlation of epizootiological observations with experimental data: chemical induction of chromatophoromas in the croaker, Nibea mitsukurii. Natl. Cancer Inst. Monogr. 65 , 139-54, (1984) Chromatophoromas in the croaker nibe, Nibea mitsukurii, are common neoplasms in feral fish which inhabit the shallow water in a unique geographic distribution along the Pacific coast of Japan. We unde... | |
| [Disease of the fins of Rhamdia sapo. Isolation of the etiological agents and experimental infection]. Rev. Argent. Microbiol. 20(1) , 37-48, (1988) During intensive culture of South-American catfish, Rhamdia sapo fingerlings an epizootic similar to fin rot was developed. Aeromonas hydrophila and Pseudomonas aeruginosa were isolated and they were ... | |
| Mutagenicity of nifurpirinol (P-7138) in Escherichia coli WP2 and Salmonella typhimurium TA100. Mutat. Res. 104(1-3) , 61-6, (1982) Nifurpirinol, 6-hydroxymethyl-2-[2-(5-nitro-2-furyl)vinyl]pyridine, which has been widely used as an antibacterial drug against diseases of fish, was found to be a potent mutagen. The mutagenic effect... |
Synonyms
| Furanace |
| Furpirinol |
| Furpirinol Furpyrinol {6-[2-(5-Nitro-2-furanyl)vinyl]-2-pyridinyl}methanol |
| Furpyrinol |
| Nifurpirinol |
| Furanace-10 |
