CAS 132183-78-9|(2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide
Introduction：Basic information about CAS 132183-78-9|(2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2H10)-5H-Dibenzo[b,f]azepine-5-carboxamide | ||
|---|---|---|---|
| CAS Number | 132183-78-9 | Molecular Weight | 246.330 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 411.0±48.0 °C at 760 mmHg |
| Molecular Formula | C15H2D10N2O | Melting Point | / |
| MSDS | / | Flash Point | 202.4±29.6 °C |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 1,2,3,4,5,6,7,8,9,10-decadeuteriobenzo[b][1]benzazepine-11-carboxamide |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological Disease |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 411.0±48.0 °C at 760 mmHg |
| Molecular Formula | C15H2D10N2O |
| Molecular Weight | 246.330 |
| Flash Point | 202.4±29.6 °C |
| Exact Mass | 246.157730 |
| PSA | 46.33000 |
| LogP | 2.67 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.670 |
| InChIKey | FFGPTBGBLSHEPO-LHNTUAQVSA-N |
| SMILES | NC(=O)N1c2ccccc2C=Cc2ccccc21 |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
Synonyms
| (H)-5H-Dibenzo[b,f]azepine-5-carboxamide |
| 5H-Dibenz[b,f]azepine-d-5-carboxamide |
