CAS 134-20-3|Methyl 2-aminobenzoate
Introduction：Basic information about CAS 134-20-3|Methyl 2-aminobenzoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methyl 2-aminobenzoate | ||
|---|---|---|---|
| CAS Number | 134-20-3 | Molecular Weight | 151.163 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 256.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H9NO2 | Melting Point | 24 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 104.4±0.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Methyl anthranilate |
|---|---|
| Synonym | More Synonyms |
Methyl 2-aminobenzoate BiologicalActivity
| Description | Methyl anthranilate, a plant spice extract, is a quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria. Methyl anthranilate has been widely employed for the preparation of edible flavor and food additives in food processing industries[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | 0.5 μL/mL of Methyl anthranilate evidently reduces biofilm formation (51.44%), swinging motility (74.86%), swarming motility (71.63%), protease activity (43.08%), and acyl-homoserine lactone (AHL) production. Methyl anthranilate might inhibit quorum sensing (QS) system in A. sobria by interfering with the biosynthesis of AHL, as well as competitively binding with receptor protein[1]. |
| References | [1]. Tingting Li, et al. Methyl anthranilate: A novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria. Food Microbiol. 2020 Apr;86:103356. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 256.0±0.0 °C at 760 mmHg |
| Melting Point | 24 °C(lit.) |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.163 |
| Flash Point | 104.4±0.0 °C |
| Exact Mass | 151.063324 |
| PSA | 52.32000 |
| LogP | 2.04 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.566 |
| InChIKey | VAMXMNNIEUEQDV-UHFFFAOYSA-N |
| SMILES | COC(=O)c1ccccc1N |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Water Solubility | slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2910 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3900 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2780 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 34800 mg/kg
- SEX/DURATION :
- male 8 day(s) pre-mating female 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
MUTATION DATA - TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 23 mg/disc
- REFERENCE :
- OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1207 No. of Facilities: 174 (estimated) No. of Industries: 3 No. of Occupations: 17 No. of Employees: 2956 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1207 No. of Facilities: 7048 (estimated) No. of Industries: 66 No. of Occupations: 71 No. of Employees: 104513 (estimated) No. of Female Employees: 49243 (estimated)
- TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 23 mg/disc
- REFERENCE :
- OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1207 No. of Facilities: 174 (estimated) No. of Industries: 3 No. of Occupations: 17 No. of Employees: 2956 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1207 No. of Facilities: 7048 (estimated) No. of Industries: 66 No. of Occupations: 71 No. of Employees: 104513 (estimated) No. of Female Employees: 49243 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | CB3325000 |
| HS Code | 2922499990 |
Customs
| HS Code | 2922439000 |
|---|---|
| Summary | 2922439000 anthranilic acid salts。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |
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Synonyms
| nerolioil,artifical |
| 1-aminobenzene-2-carboxylic acid methyl ester |
| EINECS 205-132-4 |
| 2-Aminobenzoic Acid Methyl Ester |
| Carbomethoxyaniline |
| FEMA 2682 |
| Methyl anthranylate |
| methyl o-amino-benzoate |
| methyl anthranlate |
| Methyl anthanilate |
| 2-methoxycarbonylaniline |
| Anthranilic Acid Methyl Ester |
| MFCD00007710 |
| methyl 2-amino-benzoate |
| Methylaminobenzoate |
| Methyl anthranilate |
| Methyl 2-aminobenzoate |
| NEROLI |
| Benzoic acid, 2-amino-, methyl ester |
| Nevoli oil |
