Introduction：Basic information about CAS 960539-70-2|Daprodustat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Daprodustat |
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| CAS Number | 960539-70-2 | Molecular Weight | 393.434 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C19H27N3O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Daprodustat |
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| Synonym | More Synonyms |
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Daprodustat BiologicalActivity
| Description | Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>Cardiovascular Disease |
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| In Vitro | GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2]. |
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| References | [1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71 [2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8 |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C19H27N3O6 |
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| Molecular Weight | 393.434 |
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| Exact Mass | 393.189972 |
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| PSA | 124.09000 |
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| LogP | 0.86 |
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| Appearance of Characters | white solid |
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| Index of Refraction | 1.580 |
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| InChIKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |
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| SMILES | O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O |
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| Storage condition | -20℃ |
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Synonyms
| N-[(1,3-Dicyclohexyl-2,4,6-trioxohexahydro-5-pyrimidinyl)carbonyl]glycine |
| (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine |
| GSK-1278863 |
| Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]- |
| UNII:JVR38ZM64B |
| daprodustat |
| 2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid |
| GSK1278863 |
