Introduction：Basic information about CAS 136553-96-3|JKC-301, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | JKC-301 |
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| CAS Number | 136553-96-3 | Molecular Weight | 624.72800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C32H44N6O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-[(3R,6R,9S,12R,15S)-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid |
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| Synonym | More Synonyms |
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JKC-301 BiologicalActivity
| Description | JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Vasopressin Receptor |
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| Target | Endothelin A receptor[1][2]. |
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| References | [1]. Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. [2]. Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76. |
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Chemical & Physical Properties
| Molecular Formula | C32H44N6O7 |
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| Molecular Weight | 624.72800 |
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| Exact Mass | 624.32700 |
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| PSA | 189.80000 |
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| LogP | 2.47420 |
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| InChIKey | KHRTUHCOJNQEQG-CSXHVWADSA-N |
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| SMILES | CCC(C)C1NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CC(C)C)NC1=O |
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Synonyms
| Cyclo(D-Asp-Pro-D-Ile-Leu-D-Trp) |
| JKC 301 |
| JKC-301 |
