CAS 167498-29-5|Cathepsin L inhibitor
Introduction：Basic information about CAS 167498-29-5|Cathepsin L inhibitor, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cathepsin L inhibitor | ||
|---|---|---|---|
| CAS Number | 167498-29-5 | Molecular Weight | 446.49500 |
| Density | / | Boiling Point | / |
| Molecular Formula | C26H26N2O5 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | z-fy-cho |
|---|---|
| Synonym | More Synonyms |
Cathepsin L inhibitor BiologicalActivity
| Description | Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Cathepsin |
| Target | Cathepsin L (CTSL)[1] |
| In Vitro | Z-FY-CHO (10 µM, for 1 h) pretreatment alleviated cell death induced by 6-OHDA. Z-FY-CHO inhibits the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells. Treatment with Z-FY-CHO caused more LC3-II and less P62 expression in SH-SY5Y cells treated with 6-OHDA, indicating enhancing autophagy activity, and Z-FY-CHO blocks activation of caspase-3 and PARP[1]. Treatment with the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA significantly increased the radiosensitivity of U251 cells. Both suppression and knockdown of cathepsin L in U251 cells increased irradiation-induced DNA damage and G2/M phase cell cycle arrest. Both suppression and knockdown of cathepsin L in U251 cells also increased irradiation-induced apoptosis, as shown by the increased levels of Bax and decreased levels of Bcl-2[2]. |
| In Vivo | Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation[3]. |
| References | [1]. Lingyun Li, et al. Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine. Biochem Biophys Res Commun. 2016 Feb 12;470(3):579-585. [2]. Qing-qing Zhang, et al. Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage. Acta Pharmacol Sin. 2015 Sep;36(9):1113-25. [3]. J T Woo, et al. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. Eur J Pharmacol. 1996 Apr 4;300(1-2):131-5. |
Chemical & Physical Properties
| Molecular Formula | C26H26N2O5 |
|---|---|
| Molecular Weight | 446.49500 |
| Exact Mass | 446.18400 |
| PSA | 104.73000 |
| LogP | 3.93790 |
| InChIKey | QVDJMLQSYRSZKC-UPVQGACJSA-N |
| SMILES | O=CC(Cc1ccc(O)cc1)NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1 |
Synonyms
| z-phe-tyr-cho |
| z-phe-tyr-aldehyde |
| cathepsin l inhibitor ii |
