Introduction：Basic information about CAS 25953-17-7|Minaprine (dihydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Minaprine (dihydrochloride) |
|---|
| CAS Number | 25953-17-7 | Molecular Weight | 371.30 |
|---|
| Density | / | Boiling Point | 531.2ºC at 760 mmHg |
|---|
| Molecular Formula | C17H24Cl2N4O | Melting Point | / |
|---|
| MSDS | / | Flash Point | 275.1ºC |
|---|
Names
| Name | minaprine hydrochloride |
|---|
| Synonym | More Synonyms |
|---|
Minaprine (dihydrochloride) BiologicalActivity
| Description | Minaprine 2Hcl is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression. |
|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
|---|
| References | [1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8. [2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41. |
|---|
Chemical & Physical Properties
| Boiling Point | 531.2ºC at 760 mmHg |
|---|
| Molecular Formula | C17H24Cl2N4O |
|---|
| Molecular Weight | 371.30 |
|---|
| Flash Point | 275.1ºC |
|---|
| PSA | 50.28000 |
|---|
| LogP | 3.00900 |
|---|
| Vapour Pressure | 2.29E-11mmHg at 25°C |
|---|
| InChIKey | GNUCGROXDZMCJI-UHFFFAOYSA-N |
|---|
| SMILES | Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1.Cl.Cl |
|---|
| Storage condition | 2-8℃ |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- QE3477835
- CHEMICAL NAME :
- 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 25953-17-7
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H22-N4-O.2Cl-H
- MOLECULAR WEIGHT :
- 371.35
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4823 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Endocrine - changes in thymus weight
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990
|
Synonyms
| Ag 620 |
| Agr 620 |
| Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride |
| Agr 1240 |
| 4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride |
| Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride |
| Minaprine (dihydrochloride) |
