Introduction：Basic information about CAS 475-75-2|Liriodenine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Liriodenine |
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| CAS Number | 475-75-2 | Molecular Weight | 275.258 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 531.0±19.0 °C at 760 mmHg |
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| Molecular Formula | C17H9NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 275.0±21.5 °C |
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Names
| Name | liriodenine |
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| Synonym | More Synonyms |
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Liriodenine BiologicalActivity
| Description | Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively. |
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| References | [1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 531.0±19.0 °C at 760 mmHg |
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| Molecular Formula | C17H9NO3 |
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| Molecular Weight | 275.258 |
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| Flash Point | 275.0±21.5 °C |
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| Exact Mass | 275.058258 |
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| PSA | 48.42000 |
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| LogP | 3.30 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.768 |
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| InChIKey | MUMCCPUVOAUBAN-UHFFFAOYSA-N |
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| SMILES | O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RB6036000
- CHEMICAL NAME :
- Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2-(methylenedioxy)-
- CAS REGISTRY NUMBER :
- 475-75-2
- BEILSTEIN REFERENCE NO. :
- 0273167
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C17-H9-NO3
- MOLECULAR WEIGHT :
- 975.26
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHREEB Pharmaceutical Research. (Thieme Inc., 381 Park Ave. S, New York, NY 10016) No.1- 1984- Volume(issue)/page/year: 4,495,1987
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Safety Information
Synonyms
| Spermatheridin |
| Oxoushinsunine |
| 8H-[1,3]Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one |
| 8H-1,3-Benzodioxolo[6,5,4-de]benzo[g]quinolin-8-one |
| 8H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-one (9CI) |
| 8H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-8-one |
| Liriodenine |
| Ushinsunine,oxo |
| Spermatheridine |
| Micheline B |
| Oxoushinsunin |
