Introduction：Basic information about CAS 134377-69-8|Safironil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Safironil |
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| CAS Number | 134377-69-8 | Molecular Weight | 309.36100 |
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| Density | 1.124g/cm3 | Boiling Point | 563.9ºC at 760mmHg |
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| Molecular Formula | C15H23N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | 294.9ºC |
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Names
| Name | 2-N,4-N-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide |
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| Synonym | More Synonyms |
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Safironil BiologicalActivity
| Description | Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| References | [1]. NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012) [2]. Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152(1):279-87. |
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Chemical & Physical Properties
| Density | 1.124g/cm3 |
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| Boiling Point | 563.9ºC at 760mmHg |
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| Molecular Formula | C15H23N3O4 |
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| Molecular Weight | 309.36100 |
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| Flash Point | 294.9ºC |
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| Exact Mass | 309.16900 |
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| PSA | 93.04000 |
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| LogP | 1.57990 |
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| Vapour Pressure | 9.67E-13mmHg at 25°C |
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| Index of Refraction | 1.514 |
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| InChIKey | HLSXICGBWKECLM-UHFFFAOYSA-N |
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| SMILES | COCCCNC(=O)c1ccnc(C(=O)NCCCOC)c1 |
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Synonyms
| n,n'-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide |
| UNII-CK4M8AX1LN |
| N,N'-di-(3-methoxypropyl)pyridine-2,4-dicarboxamide |
| Safironil |
