CAS 1603-40-3|3-Methylpyridin-2-amine

Introduction：Basic information about CAS 1603-40-3|3-Methylpyridin-2-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles5
7. Synonyms

Common Name	3-Methylpyridin-2-amine
CAS Number	1603-40-3	Molecular Weight	108.141
Density	1.1±0.1 g/cm3	Boiling Point	220.9±20.0 °C at 760 mmHg
Molecular Formula	C₆H₈N₂	Melting Point	29-31 °C(lit.)
MSDS	ChineseUSA	Flash Point	111.7±0.0 °C
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	2-Amino-3-picoline
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	220.9±20.0 °C at 760 mmHg
Melting Point	29-31 °C(lit.)
Molecular Formula	C₆H₈N₂
Molecular Weight	108.141
Flash Point	111.7±0.0 °C
Exact Mass	108.068748
PSA	38.91000
LogP	1.08
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.574
InChIKey	RGDQRXPEZUNWHX-UHFFFAOYSA-N
SMILES	Cc1cccnc1N
Water Solubility	SOLUBLE

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1850000

CHEMICAL NAME :: Pyridine, 2-amino-3-methyl-

CAS REGISTRY NUMBER :: 1603-40-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ BZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 36,491,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01585

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H311-H331-H373
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S36/37/39-S45-S37/39-S28A-S26
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	US1850000
Packaging Group	II
Hazard Class	6.1
HS Code	29333999

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles5

Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes.

J. Enzyme Inhib. Med. Chem. 26(1) , 104-14, (2011)

Two novel proton transfer compounds were prepared between 2,4-dichloro-5-sulphamoylbenzoic acid (lasamide) (Hsba) and ethylenediamine (en), namely ethane-1,2-diaminium 2,4-dichloro-5-sulphamoylbenzoat...

Comutagenesis-III. In vitro metabolism of 2-amino-3-methylpyridine: the effect of various potential inhibitors, activators and inducers.

Xenobiotica 27(11) , 1103-11, (1997)

1. The effects of various potential inhibitors, activators and inducers on the metabolism of the comutagen 2-amino-3-methylpyridine (2A3MP) by rabbit hepatic microsomes and S9 supernatants have been s...

Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.

Anticancer Res. 17(5A) , 3485-91, (1997)

The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-am...

Synonyms

MFCD00006320

3-methylpyridin-2-amine

2-Pyridinamine, 3-methyl-

2-Amino-3-picoline

3-Methyl-2-pyridinamine

3-Methylpyridin-2-amin

EINECS 216-501-4

2-Amino-3-methylpyridine

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