CAS 36531-78-9|Ikarugamycin

Introduction：Basic information about CAS 36531-78-9|Ikarugamycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ikarugamycin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles7
7. Synonyms

Common Name	Ikarugamycin
CAS Number	36531-78-9	Molecular Weight	478.62
Density	1.2±0.1 g/cm3	Boiling Point	741.9±60.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₈N₂O₄	Melting Point	/
MSDS	ChineseUSA	Flash Point	402.5±32.9 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	ikarugamycin
Synonym	More Synonyms

Ikarugamycin BiologicalActivity

Description	Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
Target	Clathrin-mediated endocytosis[1]
In Vitro	Ikarugamycin has an IC50 of 2.7 μM in H1299 cells[1].
References	[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	741.9±60.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₈N₂O₄
Molecular Weight	478.62
Flash Point	402.5±32.9 °C
Exact Mass	478.283173
PSA	95.50000
LogP	5.05
Vapour Pressure	0.0±5.6 mmHg at 25°C
Index of Refraction	1.604
InChIKey	GHXZHWYUSAWISC-ZJZJGRCGSA-N
SMILES	CCC1C(C)CC2C1C=CC1C3CC=CC(=O)NCCCC4NC(=O)C(=C(O)C=CC3CC12)C4=O
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI0625500

CHEMICAL NAME :: Ikarugamycin

CAS REGISTRY NUMBER :: 36531-78-9

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H38-N2-O4

MOLECULAR WEIGHT :: 478.69

WISWESSER LINE NOTATION :: T I5 H6 F5-17-5 A CV UVM D&MV DU NU SU C&HTTTT&J AQ L2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	T
RIDADR	UN 2811 6.1 / PGIII

Articles7

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB).

PLoS Negl. Trop. Dis. 9 , e0004041, (2015)

Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vacci...

Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold.

J. Exp. Bot. 59(11) , 3051-68, (2008)

Positively charged nanogold was used as a probe to trace the internalization of plasma membrane (PM) domains carrying negatively charged residues at an ultrastructural level. The probe revealed distin...

Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold.

J. Cell Sci. 120(Pt 21) , 3804-19, (2007)

In an attempt to dissect endocytosis in Nicotiana tabacum L. pollen tubes, two different probes--positively or negatively charged nanogold--were employed. The destiny of internalized plasma membrane d...

Synonyms

14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-

(3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-Ethyl-28-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.0.0.0]octacosa-1(28),3,13,18-tetraene-2,20,27-trione

Ikarugamycin

tu-6239 c3

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