CAS 96027-74-6|Desethyl Amiodarone Hydrochloride
Introduction：Basic information about CAS 96027-74-6|Desethyl Amiodarone Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desethyl Amiodarone Hydrochloride | ||
|---|---|---|---|
| CAS Number | 96027-74-6 | Molecular Weight | 653.719 |
| Density | / | Boiling Point | 630.3ºC at 760 mmHg |
| Molecular Formula | C23H26ClI2NO3 | Melting Point | 176-178ºC |
| MSDS | / | Flash Point | 335ºC |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride |
|---|---|
| Synonym | More Synonyms |
Desethyl Amiodarone Hydrochloride BiologicalActivity
| Description | Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| References | [1]. Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50. [2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44. |
Chemical & Physical Properties
| Boiling Point | 630.3ºC at 760 mmHg |
|---|---|
| Melting Point | 176-178ºC |
| Molecular Formula | C23H26ClI2NO3 |
| Molecular Weight | 653.719 |
| Flash Point | 335ºC |
| Exact Mass | 652.969055 |
| PSA | 51.47000 |
| LogP | 7.39680 |
| InChIKey | OCQPMJVGWGJLLG-UHFFFAOYSA-N |
| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCNCC)c(I)c1.Cl |
| Storage condition | -20°C Freezer, Under Inert Atmosphere |
| Stability | Moisture Sensitive |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
Articles1
More Articles| Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging. Anal. Chem. 87 , 6696-702, (2015) Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was use... |
Synonyms
| Desethylamiodarone hydrochloride |
| desethylamiodarone |
| (2-Butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone hydrochloride (1:1) |
| Methanone, (2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-, hydrochloride (1:1) |
| mono-N-desethylamiodarone hydrochloride |
| Desethyl Amiodarone Hydrochloride |
| Amiodarone Impurity 2 |
