CAS 1670-14-0|Benzimidamide hydrochloride
| Common Name | Benzimidamide hydrochloride | ||
|---|---|---|---|
| CAS Number | 1670-14-0 | Molecular Weight | 156.613 |
| Density | 1.09 g/cm3 | Boiling Point | 332.9ºC at 760 mmHg |
| Molecular Formula | C7H9ClN2 | Melting Point | 86-88 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 155.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Benzamidine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Benzimidamide hydrochloride BiologicalActivity
| Description | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cancer |
| Target | Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1] |
| In Vitro | Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1]. |
| References | [1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9. [2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. |
Chemical & Physical Properties
| Density | 1.09 g/cm3 |
|---|---|
| Boiling Point | 332.9ºC at 760 mmHg |
| Melting Point | 86-88 °C(lit.) |
| Molecular Formula | C7H9ClN2 |
| Molecular Weight | 156.613 |
| Flash Point | 155.1ºC |
| Exact Mass | 156.045425 |
| PSA | 49.87000 |
| LogP | 2.57270 |
| Vapour Pressure | 5.63E-05mmHg at 25°C |
| InChIKey | LZCZIHQBSCVGRD-UHFFFAOYSA-N |
| SMILES | Cl.N=C(N)c1ccccc1 |
| Water Solubility | soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 580 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CV6260000 |
| HS Code | 2925290090 |
Customs
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| BENZAMIDE HCL H2O |
| benzenecarboximidamide hydrochloride |
| EINECS 216-795-4 |
| benzamidinium chloride |
| benzamidine-hydrochloride |
| Benzamidine hydrochloride |
| BENZAMIDINE HCL |
| 2-phenylamidine hydrochloride |
| Benzenecarboximidamide hydrochloride (1:1) |
| benzamidine hydroxychloride |
| Benzamidine hydrochl |
| MFCD00013025 |
| Additive Screening |
| Benzamidine monohydrochloride |
| AMIDINOBENZENE HYDROCHLORIDE |
| amidinobenzenehydrochloride |
| Benzamidin Hydrochloride |
| Amidinobenzene hydrochloride (1:1) |
| Benzenecarboximidamide, hydrochloride (1:1) |
| Benzimidamide hydrochloride |
| phenyl amidine hydrochloride |
