Introduction：Basic information about CAS 189275-71-6|Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid) |
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| CAS Number | 189275-71-6 | Molecular Weight | 611.60 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 1250.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C28H33N7O9 | Melting Point | / |
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| MSDS | / | Flash Point | 709.9±34.3 °C |
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Names
| Name | ac-wehd-cho |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
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| Target | Caspase-1:56 pM (Ki) |
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| References | [1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. [2]. Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 1250.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C28H33N7O9 |
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| Molecular Weight | 611.60 |
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| Flash Point | 709.9±34.3 °C |
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| Exact Mass | 611.233948 |
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| PSA | 252.54000 |
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| LogP | -0.50 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.633 |
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| InChIKey | ZSZYUXBVDPGGGX-QGQQZZQASA-N |
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| SMILES | CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C=O)CC(=O)O |
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Safety Information
Synonyms
| N-ACETYL-TRP-GLU-HIS-ASPARTINAL |
| N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-histidinamide |
| AC-WEHD-ALDEHYDE |
| PASE-INHIBITOR VIII |
| Acetyl-tryptyl-glutamyl-histidyl-aspartal |
| AC-TRP-GLU-HIS-ASP-ALDEHYDE |
| PASE-1 INHIBITOR VIII |
| AC-TRP-GLU-HIS-ASP-CHO |
| N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-histidinamide |
| L-Histidinamide, N-acetyl-L-tryptophyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- |
