CAS 160521-72-2|BW-723C86
| Common Name | BW-723C86 | ||
|---|---|---|---|
| CAS Number | 160521-72-2 | Molecular Weight | 322.853 |
| Density | / | Boiling Point | 488.4ºC at 760 mmHg |
| Molecular Formula | C16H19ClN2OS | Melting Point | 203 - 205 °C |
| MSDS | USA | Flash Point | 249.2ºC |
Names
| Name | α-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride |
|---|---|
| Synonym | More Synonyms |
BW-723C86 BiologicalActivity
| Description | BW-723C86 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | 5-HT2B Receptor |
| References | [1]. Kennett GA, et, al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 1997 Feb;36(2):233-9. [2]. Kennett GA, et, al. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. 1998 Dec;37(12):1603-10. [3]. Matsumoto T, et, al. Effect of Equol on Vasocontractions in Rat Carotid Arteries Treated with High Insulin. Biol Pharm Bull. 2019;42(6):1048-1053. |
Chemical & Physical Properties
| Boiling Point | 488.4ºC at 760 mmHg |
|---|---|
| Melting Point | 203 - 205 °C |
| Molecular Formula | C16H19ClN2OS |
| Molecular Weight | 322.853 |
| Flash Point | 249.2ºC |
| Exact Mass | 322.090668 |
| PSA | 79.28000 |
| LogP | 5.20040 |
| Vapour Pressure | 1.09E-09mmHg at 25°C |
| InChIKey | PYJBJMIBANAOFJ-UHFFFAOYSA-N |
| SMILES | CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NL8504715 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles5
More Articles| Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J. Neurosci. 35 , 9580-94, (2015) Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des... | |
| BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 , 233-239, (1997) The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min... | |
| Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br. J. Pharmacol. 117 , 1443-1448, (1996) 1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis.... |
Synonyms
| 1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]propan-2-amine hydrochloride (1:1) |
| 1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]propan-2-amine,hydrochloride |
| 1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]-2-propanamine hydrochloride (1:1) |
| 1H-Indole-3-ethanamine, α-methyl-5-(2-thienylmethoxy)-, hydrochloride (1:1) |
| MFCD01321066 |
