CAS 168560-79-0|AIDA
| Common Name | AIDA | ||
|---|---|---|---|
| CAS Number | 168560-79-0 | Molecular Weight | 221.20900 |
| Density | 1.481 g/cm3 | Boiling Point | 470.4ºC at 760 mmHg |
| Molecular Formula | C11H11NO4 | Melting Point | / |
| MSDS | USA | Flash Point | 238.3ºC |
Names
| Name | (RS)-1-Aminoindan-1,5-dicarboxylicacid |
|---|---|
| Synonym | More Synonyms |
AIDA BiologicalActivity
| Description | UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>mGluR |
| Target | mGluR1a:214 μM (IC50) |
| In Vivo | UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1]. Animal Model: Naive male hooded Lister rats (320–350 g)[1] Dosage: 0.18 mg/kg Administration: I.p.; 0.5 ml per 100 g Result: Showed no gross motor abnormalities and normal righting reflexes. |
| References | [1]. Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326(2-3):105-108. [2]. Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1(2):151-161. |
Chemical & Physical Properties
| Density | 1.481 g/cm3 |
|---|---|
| Boiling Point | 470.4ºC at 760 mmHg |
| Molecular Formula | C11H11NO4 |
| Molecular Weight | 221.20900 |
| Flash Point | 238.3ºC |
| Exact Mass | 221.06900 |
| PSA | 100.62000 |
| LogP | 1.26990 |
| Vapour Pressure | 1.19E-09mmHg at 25°C |
| InChIKey | LSTPKMWNRWCNLS-UHFFFAOYSA-N |
| SMILES | NC1(C(=O)O)CCc2cc(C(=O)O)ccc21 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23 |
| MFCD00672638 |
| (R,S)-1-Aminoindane-1,5 |
| Valerenic acid |
| 1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid,1-Aminoindan-1,5-dicarboxylic acid |
