Introduction：Basic information about CAS 96478-43-2|Irindalone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Irindalone |
|---|
| CAS Number | 96478-43-2 | Molecular Weight | 408.51200 |
|---|
| Density | 1.219g/cm3 | Boiling Point | 605.7ºC at 760mmHg |
|---|
| Molecular Formula | C24H29FN4O | Melting Point | / |
|---|
| MSDS | / | Flash Point | 320.1ºC |
|---|
Names
| Name | 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidin-2-one |
|---|
| Synonym | More Synonyms |
|---|
Irindalone BiologicalActivity
| Description | Irindalone is a novel serotonin 5-HT2 antagonist. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Neurological Disease |
|---|
| Target | 5-HT2[1] |
|---|
| In Vitro | Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1]. |
|---|
| In Vivo | Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1]. |
|---|
| References | [1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. |
|---|
Chemical & Physical Properties
| Density | 1.219g/cm3 |
|---|
| Boiling Point | 605.7ºC at 760mmHg |
|---|
| Molecular Formula | C24H29FN4O |
|---|
| Molecular Weight | 408.51200 |
|---|
| Flash Point | 320.1ºC |
|---|
| Exact Mass | 408.23300 |
|---|
| PSA | 38.82000 |
|---|
| LogP | 3.18770 |
|---|
| Index of Refraction | 1.6 |
|---|
| InChIKey | GHAMYXPEZSUOCU-XZOQPEGZSA-N |
|---|
| SMILES | O=C1NCCN1CCN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1 |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| Irindalona |
| Irindalone |
| Irindalonum |
| UNII-4F39T8N10K |
