Introduction：Basic information about CAS 13752-33-5|Panidazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Panidazole |
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| CAS Number | 13752-33-5 | Molecular Weight | 232.23900 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C11H12N4O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]pyridine |
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| Synonym | More Synonyms |
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Panidazole BiologicalActivity
| Description | Panidazole is an amoebicide. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
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| In Vitro | Panidazole in concentrations of 0.02-1 mM increases the mutation frequency of Klebsiella pneumoniae, Escherichia coli K12 and Citrobacter freundii to streptomycin resistance, including streptomycin dependence, in Luria and Delbrück's fluctuation test[1]. |
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| In Vivo | In 100 cases of vaginal trichomoniasis treated with panidazole at the dose of 1.0 g per day for seven days in half of the patients and for 10 days in the other half, we obtained 50% and 60% cure rates[3]. |
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| References | [1]. Voogd CE, et al. The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat Res. 1977 Apr;48(2):155-61. [2]. Botero D, et al. Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. Trans R Soc Trop Med Hyg. 1977;71(6):508-11. |
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Chemical & Physical Properties
| Molecular Formula | C11H12N4O2 |
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| Molecular Weight | 232.23900 |
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| Exact Mass | 232.09600 |
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| PSA | 76.53000 |
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| LogP | 2.26060 |
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| InChIKey | ARYPMCPJIWUCIP-UHFFFAOYSA-N |
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| SMILES | Cc1ncc([N+](=O)[O-])n1CCc1ccncc1 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UT5660000
- CHEMICAL NAME :
- Pyridine, 4-(2-(2-methyl-5-nitroimidazol-1-yl)ethyl)-
- CAS REGISTRY NUMBER :
- 13752-33-5
- BEILSTEIN REFERENCE NO. :
- 0533483
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C11-H12-N4-O2
- MOLECULAR WEIGHT :
- 232.27
- WISWESSER LINE NOTATION :
- T6NJ D2- AT5N CNJ B1 ENW
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,155,1977
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5-nitro-2-methyl-1-[2-(4-pyridinyl)-ethyl]-imidazole |
| Panidazole |
| EINECS 237-334-3 |
| Pyridine,4-(2-(2-methyl-5-nitroimidazol-1-yl)ethyl) |
| Panidazolum |
| Panidazolum [INN-Latin] |
| Panidazole [INN:BAN] |
| Panidazol [INN-Spanish] |
| 4-[2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl]-pyridine |
