Introduction：Basic information about CAS 1310455-86-7|GNF179 (Metabolite), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GNF179 (Metabolite) |
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| CAS Number | 1310455-86-7 | Molecular Weight | 245.29500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C14H16FN3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-(4-fluorophenyl)-8,8-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine |
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| Synonym | More Synonyms |
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GNF179 (Metabolite) BiologicalActivity
| Description | GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.IC50 value: Target: Anti-parasitic agentGNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
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| References | [1]. Meister S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. |
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Chemical & Physical Properties
| Molecular Formula | C14H16FN3 |
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| Molecular Weight | 245.29500 |
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| Exact Mass | 245.13300 |
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| PSA | 29.85000 |
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| LogP | 2.85630 |
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| InChIKey | GZVLWGZMELYUPG-UHFFFAOYSA-N |
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| SMILES | CC1(C)NCCn2cc(-c3ccc(F)cc3)nc21 |
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| Storage condition | 2-8℃ |
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Synonyms
| GNF179 METABOLITE |
| GNF179 (Metabolite) |
