CAS 25152-20-9|Thymidine,5'-amino-5'-deoxy-
| Common Name | Thymidine,5'-amino-5'-deoxy- | ||
|---|---|---|---|
| CAS Number | 25152-20-9 | Molecular Weight | 241.24 |
| Density | 1.394 g/cm3 | Boiling Point | / |
| Molecular Formula | C10H15N3O4 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | 5'-amino-5'-deoxythymidine |
|---|---|
| Synonym | More Synonyms |
Thymidine,5'-amino-5'-deoxy- BiologicalActivity
| Description | 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
Chemical & Physical Properties
| Density | 1.394 g/cm3 |
|---|---|
| Molecular Formula | C10H15N3O4 |
| Molecular Weight | 241.24 |
| Exact Mass | 241.10600 |
| PSA | 110.34000 |
| Index of Refraction | 1.565 |
| InChIKey | PYWLBQPICCQJFF-XLPZGREQSA-N |
| SMILES | Cc1cn(C2CC(O)C(CN)O2)c(=O)[nH]c1=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles29
More Articles| Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay. Biochem. Pharmacol. 35(14) , 2359-65, (1986) A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carb... | |
| Novel acyclic amide-conjugated nucleosides and their analogues. Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009) An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensin... | |
| Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes. Carcinogenesis 13(4) , 699-702, (1992) Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the... |
Synonyms
| 5'-Amino-5'-deoxy-D-thymidine |
| 5'-amino-3'-hydroxythymidine |
| 5'-amino-5'-deoxy-thymidine |
| 5'-deoxy-5'-aminothymidine |
| 5'-deoxy-5'-amino-deoxythymidine |
