CAS 61135-33-9|5-Ethynyl-2'-deoxyuridine

Introduction：Basic information about CAS 61135-33-9|5-Ethynyl-2'-deoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5-Ethynyl-2'-deoxyuridine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles66
7. Synonyms

Common Name	5-Ethynyl-2'-deoxyuridine
CAS Number	61135-33-9	Molecular Weight	252.22300
Density	1.55g/cm3	Boiling Point	/
Molecular Formula	C₁₁H₁₂N₂O₅	Melting Point	199 °C
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS08	Signal Word	Danger

Names

Name	5-Ethynyl-2′-deoxyuridine, (EdU)
Synonym	More Synonyms

5-Ethynyl-2'-deoxyuridine BiologicalActivity

Description	5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density	1.55g/cm3
Melting Point	199 °C
Molecular Formula	C₁₁H₁₂N₂O₅
Molecular Weight	252.22300
Exact Mass	252.07500
PSA	104.55000
Index of Refraction	1.644
InChIKey	CDEURGJCGCHYFH-DJLDLDEBSA-N
SMILES	C#Cc1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7510000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-ethynyl-

CAS REGISTRY NUMBER :: 61135-33-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-N2-O5

MOLECULAR WEIGHT :: 252.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lung

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,317,1983

Safety Information

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H340-H361
Precautionary Statements	P201-P281-P308 + P313
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Articles66

Oncogene-mediated regulation of p53 ISGylation and functions.

Oncotarget 5(14) , 5808-18, (2014)

Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of th...

CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.

Sci. Rep. 5 , 17548, (2015)

Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privi...

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.

PLoS Negl. Trop. Dis. 9 , e0003853, (2015)

Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrat...

Synonyms

5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

5-Ethynyl-2'-deoxyuridine

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