CAS 36357-77-4|phosphoramidon

Introduction：Basic information about CAS 36357-77-4|phosphoramidon, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. phosphoramidon BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	phosphoramidon
CAS Number	36357-77-4	Molecular Weight	543.50400
Density	1.48 g/cm3	Boiling Point	/
Molecular Formula	C₂₃H₃₄N₃O₁₀P	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	phosphoramidon
Synonym	More Synonyms

phosphoramidon BiologicalActivity

Description	Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].
Related Catalog	Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMPSignaling Pathways >>Metabolic Enzyme/Protease >>Neprilysin
Target	Microbial Metabolite
In Vitro	Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes[5].
In Vivo	Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats[4]. Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats[5]. Animal Model: Male Sprague-Dawley rats[4] Dosage: 0.25 mg/kg per min Administration: Intravenous injection Result: Markedly suppressed the hypertensive effect of big endothelin-1.

Chemical & Physical Properties

Density	1.48 g/cm3
Molecular Formula	C₂₃H₃₄N₃O₁₀P
Molecular Weight	543.50400
Exact Mass	543.19800
PSA	220.48000
LogP	1.01040
Index of Refraction	1.631
InChIKey	ZPHBZEQOLSRPAK-XLCYBJAPSA-N
SMILES	CC(C)CC(NP(=O)(O)OC1OC(C)C(O)C(O)C1O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6688000

CHEMICAL NAME :: L-Tryptophan, N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxypho sphinyl)-L-leucyl)-

CAS REGISTRY NUMBER :: 36357-77-4

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H34-N3-O10-P

MOLECULAR WEIGHT :: 543.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,621,1973

Safety Information

Safety Phrases	22-24/25

Synonyms

PHOSPHORAMIDON SODIUM SALT

yptophan

phophoramidon

eucyl)

PHOSPHORAMIDON

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