Introduction：Basic information about CAS 78263-90-8|2-Methyl-5-HT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Methyl-5-HT |
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| CAS Number | 78263-90-8 | Molecular Weight | 190.24200 |
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| Density | 1.242g/cm3 | Boiling Point | 420.9ºC at 760 mmHg |
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| Molecular Formula | C11H14N2O | Melting Point | / |
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| MSDS | / | Flash Point | 208.4ºC |
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Names
| Name | 2-methylserotonin |
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| Synonym | More Synonyms |
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2-Methyl-5-HT BiologicalActivity
| Description | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1]. |
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| Target | 5-HT3 Receptor |
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| In Vivo | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) significantly decreases time of immobility thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects. |
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| References | [1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84. |
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Chemical & Physical Properties
| Density | 1.242g/cm3 |
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| Boiling Point | 420.9ºC at 760 mmHg |
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| Molecular Formula | C11H14N2O |
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| Molecular Weight | 190.24200 |
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| Flash Point | 208.4ºC |
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| Exact Mass | 190.11100 |
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| PSA | 62.04000 |
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| LogP | 2.38340 |
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| Index of Refraction | 1.687 |
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| InChIKey | WYWNEDARFVJQSG-UHFFFAOYSA-N |
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| SMILES | Cc1[nH]c2ccc(O)cc2c1CCN |
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Safety Information
| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Methyl-5-HT |
| Lopac-M-109 |
| 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol |
| 2-Me 5-HT |
| 2-Methyl-5-hydroxytryptamine |
| Tocris-0558 |
