CAS 3131-23-5|4-hydroxyestrone
| Common Name | 4-hydroxyestrone | ||
|---|---|---|---|
| CAS Number | 3131-23-5 | Molecular Weight | 286.36500 |
| Density | 1.241g/cm3 | Boiling Point | 468.2ºC at 760mmHg |
| Molecular Formula | C18H22O3 | Melting Point | 260-263ºC |
| MSDS | ChineseUSA | Flash Point | 251.1ºC |
Names
| Name | 4-hydroxyestrone |
|---|---|
| Synonym | More Synonyms |
4-hydroxyestrone BiologicalActivity
| Description | 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| Target | Human Endogenous Metabolite |
| References | [1]. Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283. |
Chemical & Physical Properties
| Density | 1.241g/cm3 |
|---|---|
| Boiling Point | 468.2ºC at 760mmHg |
| Melting Point | 260-263ºC |
| Molecular Formula | C18H22O3 |
| Molecular Weight | 286.36500 |
| Flash Point | 251.1ºC |
| Exact Mass | 286.15700 |
| PSA | 57.53000 |
| LogP | 3.52300 |
| Index of Refraction | 1.61 |
| InChIKey | XQZVQQZZOVBNLU-QDTBLXIISA-N |
| SMILES | CC12CCC3c4ccc(O)c(O)c4CCC3C1CCC2=O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 30,343,1977
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | KG7749500 |
Articles26
More Articles| Improved profiling of estrogen metabolites by orbitrap LC/MS. Steroids 99 , 84-90, (2015) Estrogen metabolites are important biomarkers to evaluate cancer risks and metabolic diseases. Due to their low physiological levels, a sensitive and accurate method is required, especially for the qu... | |
| Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chem. Res. Toxicol. 23(8) , 1365-73, (2010) Metabolic activation of estrogens to catechols and further oxidation to highly reactive o-quinones generates DNA damage including apurinic/apyrimidinic (AP) sites. 4-Hydroxyequilenin (4-OHEN) is the m... | |
| Menstrual cycle effects on urinary estrogen metabolites. J. Clin. Endocrinol. Metab. 84(11) , 3914-8, (1999) Endogenous estrogen metabolism may play an important role in the pathogenesis of hormone-related cancers, most notably breast cancer. Despite the importance of estrogen metabolism, little is known abo... |
Synonyms
| 4-Hydroxy Estrone |
| MFCD00079358 |
| (8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one |
| 4-HydroxyEstrone |
