Introduction：Basic information about CAS 96020-91-6|Eflornithine (hydrochloride, hydrate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Eflornithine (hydrochloride, hydrate) |
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| CAS Number | 96020-91-6 | Molecular Weight | 236.64500 |
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| Density | 1.293g/cm3 | Boiling Point | 347ºC at 760mmHg |
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| Molecular Formula | C6H15ClF2N2O3 | Melting Point | >210ºC (dec.) |
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| MSDS | / | Flash Point | 163.7ºC |
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Names
| Name | DL-α-Difluoromethylornithine Hydrochloride Monohydrate |
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| Synonym | More Synonyms |
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Eflornithine (hydrochloride, hydrate) BiologicalActivity
| Description | Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
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| In Vivo | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. |
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| Animal Admin | Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (-50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3]. |
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| References | [1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312. |
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Chemical & Physical Properties
| Density | 1.293g/cm3 |
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| Boiling Point | 347ºC at 760mmHg |
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| Melting Point | >210ºC (dec.) |
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| Molecular Formula | C6H15ClF2N2O3 |
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| Molecular Weight | 236.64500 |
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| Flash Point | 163.7ºC |
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| Exact Mass | 236.07400 |
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| PSA | 98.57000 |
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| LogP | 1.91080 |
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| InChIKey | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
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| SMILES | Cl.NCCCC(N)(C(=O)O)C(F)F.O |
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| Storage condition | 2~8°C |
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Safety Information
Customs
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrate,hydrochloride |
| Eflornithine (hydrochloride, hydrate) |
