CAS 96574-01-5|Salvianolic acid A
| Common Name | Salvianolic acid A | ||
|---|---|---|---|
| CAS Number | 96574-01-5 | Molecular Weight | 494.447 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 858.7±65.0 °C at 760 mmHg |
| Molecular Formula | C26H22O10 | Melting Point | 164-167ºC |
| MSDS | ChineseUSA | Flash Point | 292.9±27.8 °C |
Names
| Name | Salvianolic Acid A |
|---|---|
| Synonym | More Synonyms |
Salvianolic acid A BiologicalActivity
| Description | Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>MMPNatural Products >>Acids and AldehydesResearch Areas >>Inflammation/Immunology |
| Target | MMP-9 |
| In Vivo | A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain[1]. |
| References | [1]. Zhang W, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 858.7±65.0 °C at 760 mmHg |
| Melting Point | 164-167ºC |
| Molecular Formula | C26H22O10 |
| Molecular Weight | 494.447 |
| Flash Point | 292.9±27.8 °C |
| Exact Mass | 494.121307 |
| PSA | 184.98000 |
| LogP | 4.23 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.790 |
| InChIKey | YMGFTDKNIWPMGF-UCPJVGPRSA-N |
| SMILES | O=C(C=Cc1ccc(O)c(O)c1C=Cc1ccc(O)c(O)c1)OC(Cc1ccc(O)c(O)c1)C(=O)O |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Water Solubility | H2O: ≥19mg/mL |
Safety Information
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles32
More Articles| Surfactant-coated graphitized multiwalled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids. Electrophoresis 36(7-8) , 1055-63, (2015) This report describes the use of surfactant-coated graphitized multiwalled carbon nanotubes (SC-GMWNTs) as a novel pseudostationary phase in CE with diode array detection for the determination of phen... | |
| Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. Eur. J. Mass Spectrom. (Chichester, Eng.) 17(4) , 395-403, (2011) Salvianolic acid A, salvianolic acid B, danshensu, protocatechuic aldehyde, rosmarinic acid and lithospermic acid are the six major active constituents in Danshen injection. In this study, a rapid, se... | |
| In silico analysis and experimental validation of molecular mechanisms of salvianolic acid A-inhibited LPS-stimulated inflammation, in RAW264.7 macrophages. Cell Prolif. 46(5) , 595-605, (2013) The aim of this study was to explore mechanisms by which salvianolic acid A (SAA) revealed its anti-inflammatory activity, in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.Nitric oxide (NO) conce... |
Synonyms
| (2R)-3-(3,4-Dihydroxyphenyl)-2-{[(2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}-2-propenoyl]oxy}propanoic acid |
| Benzenepropanoic acid, α-[[(2E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)- |
| (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid |
| (2R)-3-(3,4-Dihydroxyphenyl)-2-{[(2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}prop-2-enoyl]oxy}propanoic acid |
