CAS 254877-67-3|ataciguat
Introduction：Basic information about CAS 254877-67-3|ataciguat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ataciguat | ||
|---|---|---|---|
| CAS Number | 254877-67-3 | Molecular Weight | 576.493 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C21H19Cl2N3O6S3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | ataciguat |
|---|---|
| Synonym | More Synonyms |
ataciguat BiologicalActivity
| Description | Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Guanylate Cyclase |
| Target | soluble guanylate cyclase[1] |
| In Vitro | Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings[2]. Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells[2]. Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol[3]. |
| References | [1]. Schindler U, et, al. Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase. Mol Pharmacol. 2006 Apr;69(4):1260-8. [2]. Martinelli AM, et, al. In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation. J Pharm Pharm Sci. 2018;21(1):38-45. [3]. Çakmak E, et, al. Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi. Balkan Med J. 2016 Jul;33(4):453-7. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H19Cl2N3O6S3 |
| Molecular Weight | 576.493 |
| Exact Mass | 574.981323 |
| PSA | 166.88000 |
| LogP | 6.08 |
| Index of Refraction | 1.685 |
| InChIKey | PQHLRGARXNPFCF-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)s1 |
| Storage condition | 2-8°C |
Synonyms
| 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide |
| Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]- |
| 5-Chloro-2-{[(5-chloro-2-thienyl)sulfonyl]amino}-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide |
| hmr 1766 |
| ataciguat |
