CAS 135459-87-9|Strontium Ranelate

Introduction：Basic information about CAS 135459-87-9|Strontium Ranelate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Strontium Ranelate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Strontium Ranelate
CAS Number	135459-87-9	Molecular Weight	513.49
Density	1.8±0.1 g/cm3	Boiling Point	778.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₂H₆N₂O₈SSr₂	Melting Point	>310°C (dec.)
MSDS	ChineseUSA	Flash Point	424.8±32.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2,2'-((5-Carboxy-4-(carboxymethyl)-3-cyanothiophen-2-yl)azanediyl)diacetic acid, distrontium salt
Synonym	More Synonyms

Strontium Ranelate BiologicalActivity

Description	Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>CaSRResearch Areas >>Metabolic Disease
References	[1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12. [2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5. [3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10 [4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328 [5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179.

Description

Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>CaSRResearch Areas >>Metabolic Disease

References

[1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12.

[2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.

[3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10

[4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328

[5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179.

Chemical & Physical Properties

Density	1.8±0.1 g/cm3
Boiling Point	778.8±60.0 °C at 760 mmHg
Melting Point	>310°C (dec.)
Molecular Formula	C₁₂H₆N₂O₈SSr₂
Molecular Weight	513.49
Flash Point	424.8±32.9 °C
PSA	160.47000
LogP	-0.90
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.695
InChIKey	XXUZFRDUEGQHOV-UHFFFAOYSA-J
SMILES	N#Cc1c(N(CC(=O)[O-])CC(=O)[O-])sc(C(=O)[O-])c1CC(=O)[O-].[Sr+2].[Sr+2]
Storage condition	-20°C Freezer
Water Solubility	H2O: soluble1mg/mL, clear (warmed)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P280
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36/37
RIDADR	3077
RTECS	XM7581000
HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-

5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid

5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid

Strontium Ranelate

Ranelic Acid Strontium Salt

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