Introduction：Basic information about CAS 131926-99-3|Lansoprazole Sulfone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lansoprazole Sulfone |
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| CAS Number | 131926-99-3 | Molecular Weight | 385.361 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 555.6±60.0 °C at 760 mmHg |
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| Molecular Formula | C16H14F3N3O3S | Melting Point | 207ºC(dec.) |
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| MSDS | / | Flash Point | 289.8±32.9 °C |
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Names
| Name | Lansoprazole Sulfone |
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| Synonym | More Synonyms |
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Lansoprazole Sulfone BiologicalActivity
| Description | Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Proton Pump |
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| References | [1]. Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718. [2]. Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61(4):450-8. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 555.6±60.0 °C at 760 mmHg |
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| Melting Point | 207ºC(dec.) |
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| Molecular Formula | C16H14F3N3O3S |
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| Molecular Weight | 385.361 |
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| Flash Point | 289.8±32.9 °C |
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| Exact Mass | 385.070801 |
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| PSA | 93.32000 |
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| LogP | 4.46 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.581 |
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| InChIKey | TVMJMCGRSSSSDJ-UHFFFAOYSA-N |
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| SMILES | Cc1c(OCC(F)(F)F)ccnc1CS(=O)(=O)c1nc2ccccc2[nH]1 |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Lansoprazole Related Compound A |
| 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfonyl]-1H-benzimidazole |
| 1H-Benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]- |
| 2-({[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl}sulfonyl)-1H-benzimidazole |
| 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole |
