Introduction：Basic information about CAS 36417-86-4|N-p-trans-Coumaroyltyramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-p-trans-Coumaroyltyramine |
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| CAS Number | 36417-86-4 | Molecular Weight | 283.322 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 586.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C17H17NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 308.5±30.1 °C |
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Names
| Name | (2E)-3-(4-Hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide |
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| Synonym | More Synonyms |
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N-p-trans-Coumaroyltyramine BiologicalActivity
| Description | N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| Target | IC50: 122 μM (AChE)[2] |
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| References | [1]. Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5. [2]. Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 586.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C17H17NO3 |
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| Molecular Weight | 283.322 |
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| Flash Point | 308.5±30.1 °C |
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| Exact Mass | 283.120850 |
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| PSA | 69.56000 |
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| LogP | 2.24 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.655 |
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| InChIKey | RXGUTQNKCXHALN-BJMVGYQFSA-N |
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| SMILES | O=C(C=Cc1ccc(O)cc1)NCCc1ccc(O)cc1 |
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| Storage condition | 2-8℃ |
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Safety Information
Synonyms
| p-Coumaroyltyramine |
| 2-Propenamide, 3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-, (2E)- |
| (2E)-3-(4-Hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide |
| (2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide |
| N-trans-p-cumaroyltyramine |
| N-p-trans-Coumaroyltyramine |
| Paprazine |
