CAS 96206-92-7|MPEP

Introduction：Basic information about CAS 96206-92-7|MPEP, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. MPEP BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	MPEP
CAS Number	96206-92-7	Molecular Weight	193.24
Density	/	Boiling Point	336.3ºC at 760mmHg
Molecular Formula	C₁₄H₁₁N	Melting Point	/
MSDS	/	Flash Point	144.8ºC

Names

Name	MPEP hydrochloride,2-Methyl-6-(phenylethynyl)pyridinehydrochloride
Synonym	More Synonyms

MPEP BiologicalActivity

Description	MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Related Catalog	Research Areas >>Neurological Disease
References	[1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. [2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599. [3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

Description

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Related Catalog

Research Areas >>Neurological Disease

References

[1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

[3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

Chemical & Physical Properties

Boiling Point	336.3ºC at 760mmHg
Molecular Formula	C₁₄H₁₁N
Molecular Weight	193.24
Flash Point	144.8ºC
PSA	12.89000
LogP	3.59180
InChIKey	NEWKHUASLBMWRE-UHFFFAOYSA-N
SMILES	Cc1cccc(C#Cc2ccccc2)n1
Storage condition	Desiccate at +4°C

Safety Information

HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

MPEP,HCl

MFCD02262119

Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)

MPEP

2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1)

2-methyl-6-phenylethynyl-pyridine

2-Methyl-6-phenylaethinyl-pyridin

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