Introduction：Basic information about CAS 36376-47-3|4-Methylhistamine dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Methylhistamine dihydrochloride |
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| CAS Number | 36376-47-3 | Molecular Weight | 198.09400 |
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| Density | 1.1g/cm3 | Boiling Point | 345ºC at 760 mmHg |
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| Molecular Formula | C6H13Cl2N3 | Melting Point | / |
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| MSDS | / | Flash Point | 189.3ºC |
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Names
| Name | 2-(5-methyl-1H-imidazol-4-yl)ethanamine,dihydrochloride |
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| Synonym | More Synonyms |
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4-Methylhistamine dihydrochloride BiologicalActivity
| Description | 4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | histamine 4 receptor[1] |
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| References | [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. |
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Chemical & Physical Properties
| Density | 1.1g/cm3 |
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| Boiling Point | 345ºC at 760 mmHg |
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| Molecular Formula | C6H13Cl2N3 |
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| Molecular Weight | 198.09400 |
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| Flash Point | 189.3ºC |
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| Exact Mass | 197.04900 |
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| PSA | 54.70000 |
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| LogP | 2.52360 |
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| Index of Refraction | 1.558 |
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| InChIKey | BVJIXYJOFWYOBL-UHFFFAOYSA-N |
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| SMILES | Cc1[nH]cnc1CCN.Cl.Cl |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NI3505800
- CHEMICAL NAME :
- Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride
- CAS REGISTRY NUMBER :
- 36376-47-3
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H11-N3.2Cl-H
- MOLECULAR WEIGHT :
- 198.12
- WISWESSER LINE NOTATION :
- T5M CNJ D2Z E1 &GH 2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 991 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - pleural effusion
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 198 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933290090 |
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Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride |
| 5-metilistamina diclorinato |
| 5-Methylhistamine dihydrochloride |
| 5-Methyl-1H-imidazole-4-ethanamine dihydrochloride |
| 2-methylhistamine dihydrochloride |
| 5-metilistamina dicloridrato |
| 4-Methylhistamine dihydrochloride |
