CAS 130-61-0|Thioridazine hydrochloride
Introduction：Basic information about CAS 130-61-0|Thioridazine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thioridazine hydrochloride | ||
|---|---|---|---|
| CAS Number | 130-61-0 | Molecular Weight | 407.035 |
| Density | / | Boiling Point | 515.7ºC at 760 mmHg |
| Molecular Formula | C21H27ClN2S2 | Melting Point | 158-1600C |
| MSDS | ChineseUSA | Flash Point | 265.7ºC |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | thioridazine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Thioridazine hydrochloride BiologicalActivity
| Description | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
Chemical & Physical Properties
| Boiling Point | 515.7ºC at 760 mmHg |
|---|---|
| Melting Point | 158-1600C |
| Molecular Formula | C21H27ClN2S2 |
| Molecular Weight | 407.035 |
| Flash Point | 265.7ºC |
| Exact Mass | 406.130432 |
| PSA | 57.08000 |
| LogP | 6.69050 |
| Vapour Pressure | 9.65E-11mmHg at 25°C |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| SMILES | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2.Cl |
| Storage condition | Desiccate at RT |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 864 mg/kg/18D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Endocrine - evidence of thyroid hyperfunction Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1060 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 71 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg/30D
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,403,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84573 No. of Facilities: 83 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 330 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84573 No. of Facilities: 135 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4095 (estimated) No. of Female Employees: 2136 (estimated)
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg/30D
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,403,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84573 No. of Facilities: 83 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 330 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84573 No. of Facilities: 135 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4095 (estimated) No. of Female Employees: 2136 (estimated)
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335-H410 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful;N:Dangerousfortheenvironment; |
| Risk Phrases | R22;R36/37/38;R50/53 |
| Safety Phrases | S26-S36-S60-S61 |
| RIDADR | UN 3077 9/PG 3 |
| RTECS | SP2275000 |
Articles11
More Articles| Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... | |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened... | |
| Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis. Tuberculosis (Edinb.) 94(6) , 695-700, (2014) Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine potentiated the activities of both isoniazid and ri... |
Synonyms
| 10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride (1:1) |
| 2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine hydrochloride |
| 10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazinhydrochlorid |
| 10-[2-(1-méthylpipéridin-2-yl)éthyl]-2-(méthylsulfanyl)-10H-phénothiazine chlorhydrate |
| Thioridazine hydrochloride |
| EINECS 204-992-8 |
| 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine,hydrochloride |
| MFCD00012655 |
| Novoridazine |
| 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, hydrochloride (1:1) |
| Stalleril |
| 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride (1:1) |
| Phenothiazine, 10-[2- (1-methyl-2-piperidyl)ethyl]-2-(methylthio)-, monohydrochloride |
| Sonapax |
| 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine monohydrochloride |
| 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylthiophenothiazine hydrochloride |
| 10H-Phenothiazine, 10-[2- (1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride |
| 10H-phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride |
| 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride |
