CAS 132489-69-1|PugNAc
| Common Name | PugNAc | ||
|---|---|---|---|
| CAS Number | 132489-69-1 | Molecular Weight | 353.33 |
| Density | 1.53g/cm3 | Boiling Point | / |
| Molecular Formula | C15H19N3O7 | Melting Point | 172-175°C |
| MSDS | USA | Flash Point | / |
Names
| Name | O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate |
|---|---|
| Synonym | More Synonyms |
PugNAc BiologicalActivity
| Description | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | (Z)-PUGNAc amplifies the incorporation of O-GlcNAc on proteins within both HeLa and HEK cell systems[1]. |
| References | [1]. Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14(3):837-846. |
Chemical & Physical Properties
| Density | 1.53g/cm3 |
|---|---|
| Melting Point | 172-175°C |
| Molecular Formula | C15H19N3O7 |
| Molecular Weight | 353.33 |
| Exact Mass | 353.12200 |
| PSA | 149.71000 |
| Index of Refraction | 1.638 |
| InChIKey | PBLNJFVQMUMOJY-JXZOILRNSA-N |
| SMILES | CC(=O)NC1C(=NOC(=O)Nc2ccccc2)OC(CO)C(O)C1O |
| Storage condition | -20℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles53
More Articles| Carbamidomethylation Side Reactions May Lead to Glycan Misassignments in Glycopeptide Analysis. Anal. Chem. 87 , 6297-302, (2015) Iodoacetamide is perhaps the most widely used reagent for the alkylation of free sulfhydryls in proteomic experiments. Here, we report that both incomplete derivatization of Cys side chains and overal... | |
| The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance. Int. J. Mol. Sci. 16 , 22856-69, (2015) Protein tyrosine phosphatase 1B (PTP1B), which can directly dephosphorylate both the insulin receptor and insulin receptor substrate 1 (IRS-1), thereby terminating insulin signaling, reportedly plays ... | |
| Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells. J. Cell Physiol. 229(10) , 1557-68, (2014) The aim of this study is to determine whether GlcN could recover the endoplasmic reticulum (ER) stress-induced dysfunction of Na(+) /glucose cotransporter (SGLT) in renal proximal tubule cells (PTCs) ... |
Synonyms
| (Z)-Pugnac,O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate |
| O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate |
