CAS 162641-16-9|HQL 79

Introduction：Basic information about CAS 162641-16-9|HQL 79, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. HQL 79 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	HQL 79
CAS Number	162641-16-9	Molecular Weight	377.48
Density	1.2±0.1 g/cm3	Boiling Point	553.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₇N₅O	Melting Point	/
MSDS	/	Flash Point	288.6±32.9 °C

Names

Name	4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
Synonym	More Synonyms

HQL 79 BiologicalActivity

Description	HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>PGE synthase
Target	IC50: 6 μM (H-PGDS)[1] Kd: 0.8 μM (H-PGDS)[1]
In Vitro	HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].
References	[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	553.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₇N₅O
Molecular Weight	377.48
Flash Point	288.6±32.9 °C
Exact Mass	377.221558
PSA	66.93000
LogP	3.94
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.619
InChIKey	TZQGXAHOROZEKN-UHFFFAOYSA-N
SMILES	c1ccc(C(OC2CCN(CCCc3nn[nH]n3)CC2)c2ccccc2)cc1

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

4-(Diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine

HQL

Piperidine, 4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]-

cc-704

2cvd

HQL-79

4-Benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]-piperidine

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