Introduction：Basic information about CAS 1670-87-7|SD-169, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SD-169 |
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| CAS Number | 1670-87-7 | Molecular Weight | 160.173 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 457.6±18.0 °C at 760 mmHg |
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| Molecular Formula | C9H8N2O | Melting Point | 159-163ºC |
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| MSDS | ChineseUSA | Flash Point | 230.6±21.2 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 1H-Indole-5-carboxamide |
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| Synonym | More Synonyms |
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SD-169 BiologicalActivity
| Description | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Metabolic Disease |
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| Target | p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50) |
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| In Vitro | SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1]. |
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| References | [1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 457.6±18.0 °C at 760 mmHg |
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| Melting Point | 159-163ºC |
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| Molecular Formula | C9H8N2O |
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| Molecular Weight | 160.173 |
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| Flash Point | 230.6±21.2 °C |
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| Exact Mass | 160.063660 |
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| PSA | 58.88000 |
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| LogP | 0.88 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.717 |
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| InChIKey | GQMYQEAXTITUAE-UHFFFAOYSA-N |
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| SMILES | NC(=O)c1ccc2[nH]ccc2c1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R22;R36/37/38 |
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| Safety Phrases | S26 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1H-Indole-5-carboxamide |
| indole-5-carboxamide |
