CAS 61788-85-0|Ethoxylated hydrogenated castor oil
| Common Name | Ethoxylated hydrogenated castor oil | ||
|---|---|---|---|
| CAS Number | 61788-85-0 | Molecular Weight | 375.864 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 529.0±50.0 °C at 760 mmHg |
| Molecular Formula | C21H23ClFNO2 | Melting Point | / |
| MSDS | USA | Flash Point | 273.8±30.1 °C |
Names
| Name | Ethoxylated hydrogenated castor oil |
|---|---|
| Synonym | More Synonyms |
Ethoxylated hydrogenated castor oil BiologicalActivity
| Description | Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vivo | 20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice[1]. PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females[1]. A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration[2]. Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil to the aqueous phase. In Webster mice, 5000 mg/kg blank nanoemulsion is given orally to mice once a day for 14 days, this nanoemulsion does not produce hazardous effects, and it has no effect on food intake[2]. |
| References | [1]. PEG-40 HYDROGENATED CASTOR OIL [2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018. [3]. PEGylated Oils as Used in Cosmetics |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.0±50.0 °C at 760 mmHg |
| Molecular Formula | C21H23ClFNO2 |
| Molecular Weight | 375.864 |
| Flash Point | 273.8±30.1 °C |
| Exact Mass | 375.140137 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.581 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles25
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| Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry. J. Chromatogr. A. 1218(40) , 7166-72, (2011) The molecular characterization of castor oil ethoxylates (CASEOs) was studied by reverse-phase liquid chromatography (RPLC) mass spectrometry (MS) and multistage mass spectrometry (MS(n)). The develop... |
Synonyms
| Brotopon |
| Einalon S |
| Eukystol |
| 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone |
| Peluces |
| Haldol |
| Halosten |
| Linton |
| Aloperidin |
| 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone |
| Sigaperidol |
| Butyrophenone, 4-[4- (p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- |
| haloperidol |
| Haloperidol [USAN:BAN:INN:JAN] |
| 1-Butanone, 4-[4- (4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- |
| 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- |
| 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one |
| Serenace |
| 4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorphenyl)butan-1-on |
| Bioperidolo |
| Dozic |
| Keselan |
