Introduction：Basic information about CAS 1352792-74-5|Verinurad, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Verinurad |
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| CAS Number | 1352792-74-5 | Molecular Weight | 348.418 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 566.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H16N2O2S | Melting Point | / |
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| MSDS | / | Flash Point | 296.5±30.1 °C |
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Names
| Name | Verinurad |
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| Synonym | More Synonyms |
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Verinurad BiologicalActivity
| Description | Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC50 of 25 nM[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>URAT1Research Areas >>Metabolic Disease |
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| Target | IC50: 25 nM (URAT1)[1] |
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| In Vitro | Verinurad inhibits the transport activity of human URAT1 in a dose-dependent manner, at high potency with an IC50 of 25 nM [1]. |
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| References | [1]. Tan PK, et al. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout. Sci Rep. 2017 Apr 6;7(1):665. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 566.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H16N2O2S |
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| Molecular Weight | 348.418 |
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| Flash Point | 296.5±30.1 °C |
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| Exact Mass | 348.093262 |
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| LogP | 3.77 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.692 |
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| InChIKey | YYBOLPLTQDKXPM-UHFFFAOYSA-N |
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| SMILES | CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(=O)O |
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| Storage condition | -20℃ |
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Synonyms
| Verinurad |
| 2-{[3-(4-Cyano-1-naphthyl)-4-pyridinyl]sulfanyl}-2-methylpropanoic acid |
| RDEA3170 |
| UNII:12WJ62D047 |
| Propanoic acid, 2-[[3-(4-cyano-1-naphthalenyl)-4-pyridinyl]thio]-2-methyl- |
