Introduction：Basic information about CAS 1354825-58-3|WEHI-345, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | WEHI-345 |
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| CAS Number | 1354825-58-3 | Molecular Weight | 401.464 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 709.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H23N7O | Melting Point | / |
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| MSDS | / | Flash Point | 382.6±32.9 °C |
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Names
| Name | N-{2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}isonicotinamide |
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| Synonym | More Synonyms |
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WEHI-345 BiologicalActivity
| Description | WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.IC50 value: 0.13 μMTarget: RIPK2in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5.in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>RIP kinaseResearch Areas >>Cancer |
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| References | [1]. Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 709.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H23N7O |
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| Molecular Weight | 401.464 |
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| Flash Point | 382.6±32.9 °C |
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| Exact Mass | 401.196411 |
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| LogP | 2.12 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.687 |
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| InChIKey | LEBSTCDZKUSVOY-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(-c2nn(C(C)(C)CNC(=O)c3ccncc3)c3ncnc(N)c23)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| N-{2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}isonicotinamide |
| 4-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]- |
| WEHI-345 |
