Introduction：Basic information about CAS 1357920-84-3|Belizatinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Belizatinib |
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| CAS Number | 1357920-84-3 | Molecular Weight | 577.733 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C33H44FN5O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | belizatinib |
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| Synonym | More Synonyms |
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Belizatinib BiologicalActivity
| Description | Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ALKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Trk ReceptorResearch Areas >>Cancer |
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| Target | IC50: 0.7 nM (ALK)[1] |
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| In Vitro | TSR-011 has antitumour activity in the clinical trials. |
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| In Vivo | TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1]. |
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| References | [1]. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C33H44FN5O3 |
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| Molecular Weight | 577.733 |
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| Exact Mass | 577.342834 |
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| LogP | 3.99 |
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| Index of Refraction | 1.631 |
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| InChIKey | WSTUJEXAPHIEIM-UHFFFAOYSA-N |
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| SMILES | CC(C)NC(=O)C1CCC(n2c(NC(=O)c3ccc(F)cc3)nc3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| 4-Fluoro-N-(6-{[4-(2-hydroxy-2-propanyl)-1-piperidinyl]methyl}-1-[cis-4-(isopropylcarbamoyl)cyclohexyl]-1H-benzimidazol-2-yl)benzamide |
| belizatinib |
| Benzamide, 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]- |
| TSR-011 |
