CAS 1627710-50-2|LJH-685

Introduction：Basic information about CAS 1627710-50-2|LJH-685, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. LJH-685 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	LJH-685
CAS Number	1627710-50-2	Molecular Weight	381.418
Density	1.3±0.1 g/cm3	Boiling Point	481.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₁F₂N₃O	Melting Point	/
MSDS	/	Flash Point	244.7±28.7 °C

Names

Name	2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol
Synonym	More Synonyms

LJH-685 BiologicalActivity

Description	LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1]
Related Catalog	Signaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK)Research Areas >>Cancer
References	[1]. Aronchik I, et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12. [2]. Davies AH, et al. Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 Aug 21;6(24):20570-7. [3]. Jain R, et al. Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J Med Chem. 2015 Sep 10;58(17):6766-83.

Description

LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM.IC50 value: 4 to 13 nM [1]Target: RSKin vitro: LJH685 efficiently inhibits RSK activity in cells. LJH685 RSK inhibition correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines only in anchorage-independent growth setting. The EC 50 values of LJH685 is 0.73 and 0.79 μM in MDA-MB-231 and H358. [1]

Related Catalog

Signaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK)Research Areas >>Cancer

References

[1]. Aronchik I, et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12.

[2]. Davies AH, et al. Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 Aug 21;6(24):20570-7.

[3]. Jain R, et al. Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J Med Chem. 2015 Sep 10;58(17):6766-83.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	481.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₁F₂N₃O
Molecular Weight	381.418
Flash Point	244.7±28.7 °C
Exact Mass	381.165283
LogP	3.31
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.601
InChIKey	IKUFKDGKRLMXEX-UHFFFAOYSA-N
SMILES	CN1CCN(c2ccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)cc2)CC1
Storage condition	-20℃

Synonyms

Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-

2,6-Difluoro-4-{4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl}phenol

LJH-685

LJH685

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