Introduction：Basic information about CAS 136834-22-5|Dmt-2'fluoro-da(bz) amidite, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dmt-2'fluoro-da(bz) amidite |
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| CAS Number | 136834-22-5 | Molecular Weight | 875.923 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C47H51FN7O7P | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-2'-fluoroadenosine |
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| Synonym | More Synonyms |
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Dmt-2'fluoro-da(bz) amidite BiologicalActivity
| Description | Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Others |
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| References | [1]. Kawasaki AM, et, al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41. |
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Chemical & Physical Properties
| Molecular Formula | C47H51FN7O7P |
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| Molecular Weight | 875.923 |
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| Exact Mass | 875.357178 |
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| LogP | 10.49 |
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| InChIKey | VCCMVPDSLHFCBB-MSIRFHFKSA-N |
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| SMILES | COc1ccc(C(OCC2OC(n3cnc4c(NC(=O)c5ccccc5)ncnc43)C(F)C2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
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Safety Information
Synonyms
| N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-2'-fluoroadenosine |
| Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2'-deoxy-2'-fluoro- |
