(Rac)-BRD0705 CAS 1597440-03-3

Introduction：Basic information about (Rac)-BRD0705 CAS 1597440-03-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

(Rac)-BRD0705 Basic information

• Product Name: (Rac)-BRD0705
• Synonyms: (Rac)-BRD0705;GSK3α,inhibit,Racemate,(Rac)BRD0705,GSK-3,Inhibitor,Glycogen synthase kinase-3,(Rac) BRD0705,(Rac)-BRD-0705,Glycogen synthase kinase 3,(Rac)-BRD0705;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-;(Rac)-BRD0705, 10 mM in DMSO;4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one
• CAS: 1597440-03-3
• MF: C20H23N3O
• MW: 321.42
• Mol File: 1597440-03-3.mol

(Rac)-BRD0705 Chemical Properties

• Boiling point: 512.0±50.0 °C(Predicted)
• density: 1.22±0.1 g/cm3(Predicted)
• form: Solid
• pka: 14.82±0.60(Predicted)
• color: Light yellow to yellow

(Rac)-BRD0705 Usage And Synthesis

Uses

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

References

[1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460
[2] Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1.