1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE CAS 73465-43-7

Introduction：Basic information about 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE CAS 73465-43-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Basic information

• Product Name: 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
• Synonyms: DMJ;DMJ, HYDROCHLORIDE;DMM;DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;DEOXYMANNONOJIRIMYCIN HCL;1,5-DIDEOXY-1,5-IMINO-D-MANNITOL, HCL;1,5-DIDEOXY-1,5-IMINO-D-MANNITOL HYDROCHLORIDE
• CAS: 73465-43-7
• MF: C6H14ClNO4
• MW: 199.63
• Product Categories: Miscellaneous Natural Products;All Inhibitors;Glycosidase Inhibitors;Inhibitors
• Mol File: 73465-43-7.mol

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemical Properties

• Melting point: 183-185°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: H2O: soluble10mg/mL
• form: Powder
• color: white to off-white
• Water Solubility: Soluble in water (50 mM)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
• InChIKey: ZJIHMALTJRDNQI-MVNLRXSJSA-N
• SMILES: Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
• CAS DataBase Reference: 73465-43-7

Safety Information

• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-37/39-26
• WGK Germany: 3
• HS Code: 2941900000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Usage And Synthesis

Description

1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC₅₀ = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.

Chemical Properties

White Crystalline Solid

Uses

Selective inhibitor of a-mannosidase

Uses

Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.

storage

+4°C

References

[1] J BISCHOFF  R K  L Liscum. The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells.[J]. The Journal of Biological Chemistry, 1986, 261 10: 4766-4774.
[2] JOYCE BISCHOFF  Rosalind K. The effect of 1-deoxymannojirimycin on rat liver α-mannosidases[J]. Biochemical and biophysical research communications, 1984, 125 1: Pages 324-331. DOI:10.1016/s0006-291x(84)80371-x
[3] ULRIKE FUHRMANN. Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides[J]. Nature, 1984, 307 5953: 755-758. DOI:10.1038/307755a0
[4] KUNIO MIYAKE  Kaoru N. Inhibition of α-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death[J]. Neurotoxicology, 2009, 30 1: Pages 144-150. DOI:10.1016/j.neuro.2008.10.010
[5] APRIL TAI. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.[J]. Journal of Biological Engineering, 2011, 5 1: 1. DOI:10.1186/1754-1611-5-1
[6] CHI-LIN LEE. Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination[J]. Biotechnology and Bioengineering, 2011, 109 6: 1551-1560. DOI:10.1002/bit.24413