Introduction：Basic information about Adrenalone CAS 99-45-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Adrenalone Basic information
| Product Name: | Adrenalone |
| Synonyms: | ADRENALONE;AKOS NCG-0050;1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanon;3,4-dihydroxy-alpha-methylaminoacetophenone;3’,4’-dihydroxy-2-(methylamino)-acetophenon;3’,4’-dihydroxy-2-(methylamino)acetophenone;4-methylaminoacetocatechol;4-methylaminoacetopyrocatechol |
| CAS: | 99-45-6 |
| MF: | C9H11NO3 |
| MW: | 181.19 |
| EINECS: | 202-756-9 |
| Product Categories: | Pharmaceutical Intermediates |
| Mol File: | 99-45-6.mol |
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Adrenalone Chemical Properties
| Melting point | 235.5°C (rough estimate) |
| Boiling point | 314.29°C (rough estimate) |
| density | 1.2375 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Aqueous Acid (Slightly) |
| form | Solid |
| pka | 7.32±0.20(Predicted) |
| color | Pale Yellow to Light Yellow |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C9H11NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,10-12H,5H2,1H3 |
| InChIKey | PZMVOUYYNKPMSI-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(O)C(O)=C1)CNC |
Safety Information
Adrenalone Usage And Synthesis
| Chemical Properties | Needle-shaped crystal. Decomposition temperature 235-236 ℃, slightly soluble in water, alcohol, ether. Its hydrochloride, melting point 243 ° C, soluble in water, soluble in ethanol, insoluble in ether. |
| Originator | Adrenalone ,Yick-Vic Chemicals andPharmaceuticals (HK) Ltd. |
| Uses | Adrenergic (ophthalmic). |
| Uses | Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor. |
| Definition | ChEBI: Adrenalone is an aromatic ketone. |
| Preparation | Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone. |
| Manufacturing Process | To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared fromchloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25,154) was added dropwise 1 part 60% solution of methylamine. Immediatelywas formed a residue of the salt of methylamine and ω-chloro-3,4-dihydroxyacetophenone. The dissolution of the salt was carried out by heatingof the mixture. Then the salt was converted in crude 3,4-dihydroxy-α-methylaminoacetophenone. The product was dissolved in dilute hydrochloricacid. To this solution was added dropwise aqueous ammonium solution toprepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone.The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenonedecomposed at temperature near 230°C and 240°C respectively. |
| Therapeutic Function | Hemostatic, Sympathomimetic, Vasoconstrictor |
Adrenalone Preparation Products And Raw materials
| Raw materials | 2-hydroxy-1-(4-hydroxyphenyl)ethanone-->Methylamine |
