Introduction：Basic information about ATROPINE METHYL NITRATE CAS 52-88-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
ATROPINE METHYL NITRATE Basic information
| Product Name: | ATROPINE METHYL NITRATE |
| Synonyms: | metropine;n-methylatropinenitrate;N-METHYLATROPINIUM NITRATE;,endo-(+/-)-,nitrate(salt);1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-methyl-,nitrate,(+-)-tropa;3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromide(+,-)-tropate;8-methylatropiniumnitrate;8-methyl-atropiniunitrate |
| CAS: | 52-88-0 |
| MF: | C18H26NO3.NO3 |
| MW: | 366.41 |
| EINECS: | 200-156-1 |
| Product Categories: | Alkaloids;Biochemistry;Tropane Alkaloids |
| Mol File: | 52-88-0.mol |
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ATROPINE METHYL NITRATE Chemical Properties
| Melting point | 163°C |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white |
| Merck | 875 |
| CAS DataBase Reference | 52-88-0(CAS DataBase Reference) |
| EPA Substance Registry System | Methylatropine nitrate (52-88-0) |
Safety Information
| Hazard Codes | Xn,T+ |
| Risk Statements | 22-26/28 |
| Safety Statements | 22-36-45-25 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | CK2800000 |
| TSCA | TSCA listed |
| Toxicity | LD50 oral in rat: 1902mg/kg |
ATROPINE METHYL NITRATE Usage And Synthesis
| Chemical Properties | mp 162-164 C |
| Originator | Methylatropine,Paganfarma |
| Uses | Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor. |
| Uses | antibacterial |
| Uses | cephalosporin antimicrobial |
| Manufacturing Process | There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methylatropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methylatropine chloride and silver nitrate) in water was added aqueous solution of26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate wasconcentrated and the methyl atropine nitrate was obtained. |
| Brand name | Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop). |
| Therapeutic Function | Anticholinergic, Mydriatic, Spasmolytic |
| Biochem/physiol Actions | Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier. |
| Safety Profile | Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES. |
ATROPINE METHYL NITRATE Preparation Products And Raw materials
| Raw materials | Atropine sulfate-->Atropine-->Barium nitrate-->Methyl nitrate-->methyl nitrate-->Methyl bromide |
