Boldine CAS 476-70-0

Introduction：Basic information about Boldine CAS 476-70-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Boldine Basic information

• Product Name: Boldine
• Synonyms: (+)-(s)-boldine;(s)-boldine;(s)-yl;1,10-dimethoxy-6a-alpha-aporphine-2,9-diol;1,10-dimethoxy-6a-alpha-aporphine-9-diol;4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth;4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl;boldin
• CAS: 476-70-0
• MF: C19H21NO4
• MW: 327.37
• EINECS: 207-509-9
• Mol File: 476-70-0.mol

Boldine Chemical Properties

• Melting point: 162-164 °C
• Boiling point: 465.27°C (rough estimate)
• density: 1.2223 (rough estimate)
• refractive index: 1.5000 (estimate)
• storage temp.: 2-8°C
• solubility: Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
• pka: 9.75±0.20(Predicted)
• form: Solid
• color: Yellow to Dark Brown
• Merck: 13,1316
• BRN: 94036
• Major Application: food and beverages forensics and toxicology veterinary
• InChI: 1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1
• InChIKey: LZJRNLRASBVRRX-ZDUSSCGKSA-N
• SMILES: COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O
• LogP: 0.837 (est)
• CAS DataBase Reference: 476-70-0(CAS DataBase Reference)
• EPA Substance Registry System: 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- (476-70-0)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 1-20-24/25-45-36-26
• RIDADR: 1544
• WGK Germany: 3
• RTECS: CE0750000
• TSCA: TSCA listed
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29399990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Boldine Usage And Synthesis

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.

Uses

antineoplastic

Uses

boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark.

Definition

ChEBI: Boldine is an aporphine alkaloid.

in vivo

Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways^[3].

• Animal Model: DSS-induced mice model^[3]
• Dosage: 50 mg/kg
• Administration: p.o.
• Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.