Introduction：Basic information about Bombesin CAS 31362-50-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Bombesin Basic information
| Product Name: | Bombesin |
| Synonyms: | Bombesin hydrate acetate salt;Bombesin acetate salt hydrate;2-l-glutamine-6-l-asparagine-alytesi;bombesin acetate;Bombesin, Free Base;BOMBESIN SYNTHETIC >97% STIMULATES GASTR IN RE;BOMBESIN;bombesin acetate hydrate |
| CAS: | 31362-50-2 |
| MF: | C71H110N24O18S |
| MW: | 1619.85 |
| EINECS: | |
| Product Categories: | Neuromedins and related;Peptide |
| Mol File: | 31362-50-2.mol |
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Bombesin Chemical Properties
| density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | 0.05 M acetic acid: 20 mg/mL, clear, colorless |
| form | Powder |
| pka | 13.04±0.46(Predicted) |
| color | White to off-white |
| Optical Rotation | -20.624〔DMF-HMPT(8：2)〕 |
| Merck | 13,1320 |
| BRN | 9611365 |
| Sequence | Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 |
| InChIKey | QXZBMSIDSOZZHK-DOPDSADYSA-N |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | BD3480000 |
| F | 10 |
| Storage Class | 11 - Combustible Solids |
Bombesin Usage And Synthesis
| Description | Bombesin is a tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function. |
| Uses | Gut tetradecapeptide with the ability to stimulate release of various hormones |
| Biological Activity | Bombesin/gastrin releasing peptide (BN/GRP) serves as an autocrine growth factor in small cell lung cancer (SCLC). Overexpression of gastrin releasing peptide receptor (GRP-R) is associated with neuroblastoma tumor aggressiveness. GRP-R modulates the important enzymes, th at participates in glucose metabolism. Bombesin, a pulmonary growth factor helps to satisfy the conditions for autocrine stimulation.', 'Tetradecapeptide originally isolated from the skin of the frog Bombina bombina. Bombesin acts at specific brain nuclei to inhibit food intake. It also increases blood glucose levels. |
| Purification Methods | Purify Bombesin by gel filtration on a small column of Sephadex G-10 and elute with 0.01 M AcOH. This procedure removes lower molecular weight contaminants which are retarded on the column. The procedure should be repeated twice, and the material should now be homogeneous on electrophoresis, and on chromatography it gives a single active spot which is negative to ninhydrin but positive to Cl2 and iodoplatinate reagents. RF on paper chromatography (n-BuOH/pyridine/AcOH/H2O :: 37.5: 25:7.5:30) is 0.55 for Bombesin and 0.65 for Alytin. [Bernardi et al. Experientia Part 1 27 166 1971, Anastasi et al. Part 2 27 873 1971.] The hydrochloride has m 185o(dec) (from EtOH) [] D -20.6o [c 0.65, Me2NCHO/(Me2N)3PO (8:2)]. [For the stimulation of inositol phosphate see Lloyd et al. Biochem J 260 813 1989.] |
Bombesin Preparation Products And Raw materials
