Introduction：Basic information about CARBETAPENTANE CITRATE CAS 23142-01-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
CARBETAPENTANE CITRATE Basic information
| Product Name: | CARBETAPENTANE CITRATE |
| Synonyms: | Atomin S;Gai-Less;CARBETAPENTANE CITRATE;CARBETAPENTANE CITRATE SALT;PENTOXIVERINE CITRATE;PENTOXYVERINE CITRATE;2-(2-(diethylamino)ethoxy)-ethano1-phenylcyclopentanecarboxylate(ester);Carbetapentane citrate/Pentoxyverine citrate |
| CAS: | 23142-01-0 |
| MF: | C26H39NO10 |
| MW: | 525.59 |
| EINECS: | 245-449-5 |
| Product Categories: | Respiratory system durgs;Intermediates & Fine Chemicals;Pharmaceuticals;Sigma receptor |
| Mol File: | 23142-01-0.mol |
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CARBETAPENTANE CITRATE Chemical Properties
| Melting point | 84-86?C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: soluble |
| form | Solid |
| color | White to Off-White |
| InChIKey | AKJDEXBCRLOVTH-UHFFFAOYSA-N |
| SMILES | C1(CCCC1)(C(=O)OCCOCCN(CC)CC)C1C=CC=CC=1.C(O)(C(=O)O)(CC(=O)O)CC(=O)O |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | GY3500000 |
CARBETAPENTANE CITRATE Usage And Synthesis
| Chemical Properties | White to Off-White Solid |
| Originator | Asthma ,Nichiiko |
| Uses | Sigma receptor agonist |
| Uses | antibacterial, antiproliferative |
| Uses | An over-the-counter cough suppressant. |
| Definition | ChEBI: Carbetapentane citrate is a carbonyl compound. |
| Manufacturing Process | 1-Phenylcyclopentane carbonitrile was obtained by treatment of phenylacetonitrile with sodium amide and 1,4-dibrombutane.
1-Phenyl-1-cyclopentane carboxylic acid was produced in the result of reaction of 1-phenylcyclopentane carbonitrile with sulfuric acid.
1-Phenyl-1-cyclopentanecarbonyl chloride was obtained by treatment of 1phenyl-1-cyclopentane carboxylic acid with thionyl chloride.
A mixture of 0.5 mol of 1-phenyl-1-cyclopentanecarbonyl chloride and of 0.5 mol of 2-(2-diethylaminoethoxy)ethanol (herein-after referred to as the amino alcohol) in 300 ml of toluene is heated under reflux for 20 h. The mixture is thereafter made alkaline by means of an aqueous solution of caustic soda and decanted; the toluenic layer is washed with water and concentrated in vacuo. The residue is distilled under high vacuum. After two fractional distillations, the 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane-carboxylate is obtained, in 85% yield. Boiling point 164°C/0.1 mm. Hg. |
| Brand name | Toclase (Pfizer). |
| Therapeutic Function | Antitussive |
| Biological Activity | A selective ligand for the σ 1 -site. |
CARBETAPENTANE CITRATE Preparation Products And Raw materials
| Raw materials | Sodium amide-->Thionyl chloride-->1,4-Dibromobutane-->6-Ethyl-3-oxa-6-azaoctanol |
