Introduction：Basic information about Carbetocin CAS 37025-55-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Carbetocin Basic information
| Product Name: | Carbetocin |
| Synonyms: | BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDE BOND BETWEEN BUTYRYL-4-YL AND CYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-1-CARBAOXYTOCIN TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCIN TRIFLUOROACETATE SALT;CARBETOCIN;CARBETOCIN TRIFLUOROACETATE SALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN |
| CAS: | 37025-55-1 |
| MF: | C45H69N11O12S |
| MW: | 988.17 |
| EINECS: | 253-312-6 |
| Product Categories: | Other APIs;Peptide;Vasopressin and Oxytocin receptor;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 37025-55-1.mol |
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Carbetocin Chemical Properties
| Melting point | 140 - 160°C |
| Boiling point | 1477.9±65.0 °C(Predicted) |
| alpha | D -69.0° (c = 0.25 in 1M acetic acid) |
| density | 1.218±0.06 g/cm3(Predicted) |
| storage temp. | -15°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 13.07±0.70(Predicted) |
| color | white to beige |
| Water Solubility | Soluble to 29.65 mg/ml in water |
| Stability: | Hygroscopic |
| InChIKey | NSTRIRCPWQHTIA-FOILTOEQNA-N |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Carbetocin Usage And Synthesis
| Description | Carbetocin is an alternative synthetic oxytocin-receptor agonist available in Canada, the United Kingdom, and other countries，but not the United States. A large multinational randomized noninferiority trial (N=29,645) found that carbetocin was noninferior to oxytocin for prevention of postpartum hemorrhage and need for additional uterotonic agents after vaginal delivery. Carbetocin has a longer duration of action than oxytocin, eliminating the need for prolonged infusion. |
| Uses | Carbetocin is an obstetric drug used to control postpartum hemorrhaging.
A new synthetic analog of oxytocin, carbetocin, is long acting and also has a rapid onset of action. It is an oxytocin receptor agonist and also stimulates milk let down due to its action on oxytocin receptors of myoepithelial cells. |
| Definition | ChEBI: Oxytocin in which the hydrogen on the phenolic hydroxy group is substituted by methyl, the amino group on the cysteine residue is substituted by hydrogen, and the sulfur of the cysteine residue is replaced by a methylene group. A synthetic carba-analogue o oxytocin, it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus. |
| Biochem/physiol Actions | Carbetocin is a potent agonist of the oxytocin receptor, with improved in vivo stability over oxytocin. |
| Side effects | One of the most commonly reported side effects of Carbetocin is hypotension, or low blood pressure. Another frequently observed side effect is nausea, often accompanied by vomiting. It can also cause headache. |
| storage | Store at -20°C |
Carbetocin Preparation Products And Raw materials
